A New Approach - Our research pursues an exciting and revolutionary alternative: targeting the pathology and underlying biology of aging itself. Therapies derived from this kind of effort have the potential to treat multiple diseases simultaneously. Research has determined that aging is largely controlled by ten (10) primary internal biological factors, now understood to be reversible. Here they are listed hierarchically, most important to least important:

1. Pineal clock- (Pineal / Hypothalmic/ Pituitary/ Superchiasmatic Nucleolus (SCN)  axis) this is the master time clock and coordinates the body's circadian rhythm and the time-cycled release of melatonin and other critical hormones and neurotransmitters.

2. Thymic involution- immune depletion, and T-cell diminution.

3. Blood signaling and transcription factors- reverse distributed blood signaling of TGF-ß1 and Oxytocin (to all cells).

4. Telomere length- Attrition of the protective chromosomal endcaps causing programmed Cellular senescence.

5. Senolytics- (autophagy, mitophagy) Accumulation of senescent zombie-like cells that inflame and signal senescence to healthy cells. Centers on the removal of cellular waste associated with aging and disease.

6. Inflammaging- Inflammatory response, altered intercellular communication and the production of inflammatory cytokine and chemokine molecules.

7. Stem Cell Exhaustion- loss of source stem cells.

8. Cellular Metabolic Efficiency (NAD, NMN, NR, Sirtuins, Resveratrol, ATP, ROS)- Energy production and mitochondrial dysfunction.

9. Epigenetic clock (DNAm cytosine methylation)- Alterations to the epigenome that control which genes are turned on and off.

10. Extra Cellular Matrix Stiffening - The decrease in elastin, in turn, increases collagen content and ECM stiffness. This causes age-related diseases such as hypertension, and atherosclerosis.